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BIX 02189

Catalog No. S1531 5 5 7 Customer Review(s) Product Citations4 Product Citation(s)
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BIX 02189 Chemical Structure

Bio Information

BIX 02189 is a selective MEK5/ERK5 inhibitor with an IC50 of 59 nM. [1] It inhibited catalytic function of purified, MEK5 enzyme. The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells. The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system. [2]

References:

[1] Biochemical and Biophysical Research Communications 2008;377：120–125

[2] JOURNAL OF BIOLOGICAL CHEMISTRY August 28, 2009;284：23564–23573

Chemical Information

Molecular Weight (WM): 440.54
Formula:

C27H28N4O2
Solubility(R.T.:25°C): DMSO 88mg/mL 
Water <1mg/mL 
Ethanol 88mg/mL 

Quality Control

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Research Area

MAPK >> MEK >> MEK Inhibitors

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Related Antibodies

Information  
Reactivity: 薛亚红

BIX 02189 has been referenced in 4 publications.

Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation.
Laminar flow activation of ERK5 leads to cytoprotective effect via CHIP-mediated p53 ubiquitination in endothelial cells.
Cadmium activates extracellular signal-regulated kinase 5 in HK-2 human renal proximal tubular cells.
Role of AP-1 family proteins in regulation of inducible nitric oxide synthase (iNOS) in human neutrophils.

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Average Customer Review

(7 customer reviews)

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  • ;THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, pp. 40722–40731
    BIX 02189 purchased from Selleck


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  • ;Biochemical and Biophysical Research Communications, 421 (2012) 490–493
    BIX 02189 purchased from Selleck


  • Click to enlarge

  • ;THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, pp. 40722–40731
    BIX 02189 purchased from Selleck


  • Click to enlarge

  • ;THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, pp. 40722–40731
    BIX 02189 purchased from Selleck


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  • ;Journal of Immunotoxicology, 2013, 10(1), 32–39
    BIX 02189 purchased from Selleck


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  • ;Biochemical and Biophysical Research Communications, 421 (2012) 490–493
    BIX 02189 purchased from Selleck


  • Click to enlarge

  • ;Dr. Franco Izzo of Institute of Biology and Experimental Medicine
    BIX 02189 purchased from Selleck

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Click to enlarge

;THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, pp. 40722–40731


Click to enlarge

;Biochemical and Biophysical Research Communications, 421 (2012) 490–493

+ See All 7 Customer Reviews of BIX 02189

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