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BIX 02188 Chemical Structure
BIX02188 is a MEK5-selective inhibitor with an IC50 of 0.8 ± 1.0 μM. It completely reversed the inhibitory effects of flow. [1] The physiological roles of ERK5 in neuronal cells have not been clarified. One reason was the lack of a selective ERK5 pharmacological inhibitor until the novel selective MEK5/ERK5 inhibitors BIX02188 and BIX02189. [2]
[1] Biochem Biophys Res Commun 2008 May 23;370(1): 159–163
[2] Mol Pharmacol 2010;77:10–16
[2] Mol Pharmacol 2010;77:10–16
| Molecular Weight (WM): | 426.51 |
|---|---|
| Formula: | C26H26N4O2 |
| Solubility(R.T.:25°C): | DMSO 43mg/mL |
| Water <1mg/mL | |
| Ethanol 3mg/mL |
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