|Clonality:||Mouse Monoclonal Antibody|
|Molecular Weight:||78 kDa|
|Sensitivity:||Bip Mouse mAb detects endogenous levels of Bip protein.|
Purified recombinant fragment of human HSPA5 expressed in E. coli.
|Storage:||Supplied in PBS, 0.005% sodium azide, PH 7.4. Store at -20°C. Stable for one year from the date of shipment.|
|Synonyms:||HSPA5 antibody; GRP78 antibody; MIF2 antibody; 78 kDa glucose-regulated proteinendoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody; immunoglobulin heavy chain-binding protein antibody; heat shock 70kDa prote|
Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells [1,2]. It was also found to be induced at the protein level by glucose starvation . When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding .