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United States (Change Country)BIBR 1532 Chemical Structure
BIBR 1532, (2-[(E)-3-naphtalen-2-yl-but-2-enoylamino]-benzoic acid), is a selective telomerase inhibitor.[1,2]This reagent inhibits the in vitro processivity of telomerase in a dose-dependent manner, with IC50 of 93 nM. The selectivity of BIBR1532 was assessed in a panel of DNA and RNA polymerases, showing that none of these enzymes was inhibited in concentrations up to 100 uM. BIBR1532 has a direct cytotoxic effect on leukemia cells but not in normal hematopoietic stem cells.[1]
[1] Blood 2005;105: 1742-1749
[2] THE JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277:15566–15572
| Molecular Weight (WM): | 331.36 |
|---|---|
| Formula: | C21H17NO3 |
| Solubility(R.T.:25°C): | DMSO 66mg/mL |
| Water <1mg/mL | |
| Ethanol 3mg/mL |
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