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Bcl-2 (B-cell lymphoma 2) is the founding pro-survival member of the Bcl-2 protein family, exerting its pro-survival function in response to a broad range of apoptotic stimuli through the inhibition of the mitochondrial outer membrane permeabilization (MOMP) process and the release of mitochondrial cytochrome c. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1001 | ABT-263 (Navitoclax) | ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively. |
 (15)
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 (10)
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| S1002 | ABT-737 | ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. |
(39)
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(8)
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| S1057 | Obatoclax mesylate (GX15-070) | Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM. |
(8)
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(3)
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| S1121 | TW-37 | TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
(4)
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(2)
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| S2812 | AT101 | AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members. |
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| S1071 | HA14-1 | HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
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| S7034 | BM-1074 | BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. |
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| S8061 | Sabutoclax | Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
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| S8048 | ABT-199 | ABT-199 is a Bcl-2-selective inhibitor with Ki < 0.010 nM. |
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