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AZD7762

Catalog No. S1532 7 Customer Review(s)

Product Citations

6 Product Citation(s)

AZD7762 Chemical Structure

Bio Information

AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.^{[1] [2]}

References:

[1] Cancer Res 2010;70:4972-4981

[2] Mol Cancer Ther 2008;7:2955-2966

Chemical Information

Molecular Weight (WM):	362.42
Formula:	C₁₇H₁₉FN₄O₂S

Solubility(R.T.:25°C):	DMSO 50mg/mL
	Water <1mg/mL
	Ethanol <1mg/mL

Quality Control

View current batch:

Purity= 97.92% H-NMR HPLC Purity= 99.01% H-NMR HPLC Purity= 97.06%

Research Area

Cell Cycle >> Chk >> Chk Inhibitors

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Related Antibodies

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Reactivity: 薛亚红

AZD7762 has been referenced in 6 publications.

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing.[Carette JE, et al. Nat Biotechnol 2011;29(6):542-6]

PubMed: 21623355

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells.[Brazelle W, et al. PLoS ONE 2010;5(12), e14335]

PubMed: 21179472

An Inverse Switch in DNA Base Excision and Strand Break Repair Contributes to Melphalan Resistance in Multiple Myeloma Cells.[Sousa MM, et al. PLoS One 2013;8(2):e55493]

PubMed: 23405159

Enhancing CHK1 inhibitor lethality in glioblastoma.[Tang Y, et al. Cancer Biol Ther 2012;13(6), 379-388]

PubMed: 22313687

Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.[Aarts M, et al. Cancer Discov 2012;2(6):524-39]

PubMed: 22628408

Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.[Mitchell C, et al. Cancer Biol Ther 2011;12(3):215-28]

PubMed: 21642769

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Average Customer Review

(7 customer reviews)

Click to enlarge
;Cancer Discovery, 2012, 2, 524-539
AZD7762 purchased from Selleck

Click to enlarge
Data from [Cancer Biol Ther 2012;13]
AZD7762 purchased from Selleck

Click to enlarge
Data from [Cancer Biol Ther 2012;13]
AZD7762 purchased from Selleck

Click to enlarge
;Cancer Biol Ther, 2011, 12(3), 215-28
AZD7762 purchased from Selleck

Click to enlarge
;Cancer Biol Ther, 2011, 12(3), 215-28.
AZD7762 purchased from Selleck

Click to enlarge
;Cancer Discov, 2012, 2(6), 524-39.
AZD7762 purchased from Selleck

Click to enlarge
;Cancer Discov, 2012, 2(6), 524-39.
AZD7762 purchased from Selleck

Quality Matters

This product has been referenced in

+ See All 6 Product Citations of AZD7762

Check our customer reviews

Click to enlarge

;Cancer Discovery, 2012, 2, 524-539

Click to enlarge

Data from [Cancer Biol Ther 2012;13]

+ See All 7 Customer Reviews of AZD7762

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