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AZD6482

Catalog No. S1462 5 5 2 Customer Review(s) Product Citations1 Product Citation(s)
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$ 170 Yes
$ 320 Yes
$ 970 Yes
 
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AZD6482 Chemical Structure

Bio Information

AZD6482 is a PI3Kβ inhibitor (IC50=0.021μM) used in antithrombotic therapy. This agent targets a process that is critical to pathological thrombus formation without interfering with normal haemostasis, which avoids the drawbacks of the existing anti-thrombotic therapy. This agent inhibits PI3Kβ/α/γ/δwith IC50 of 0.021, 1.4, 1.2, 0.08μM, respectively. It washed platelet aggregation with concentration at 6 nM.

Chemical Information

Molecular Weight (WM): 408.45
Formula:

C22H24N4O4
Solubility(R.T.:25°C): DMSO 82mg/mL 
Water <1mg/mL 
Ethanol 28mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

PI3K/Akt/mTOR >> PI3K >> PI3K Inhibitors

Recommended Screening Libraries

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Information  
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM.
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PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.
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GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively.
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ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM.
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LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, respectively.
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Related Antibodies

Information  
Clonality: Rabbit polyclonal antibody
Application: WB
Reactivity: Human,Mouse
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Clonality: Mouse Monoclonal Antibody
Application: ELISA, WB, IHC
Reactivity: Human, Mouse, Rat, Monkey
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Clonality: Rabbit Polyclonal Antibody
Application: WB
Reactivity: Human
  • 100ul
  • $ 250
Clonality: Mouse Monoclonal Antibody
Application: WB, IHC, IF-ICC
Reactivity: Human, Mouse, Rat
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Clonality: Rabbit Polyclonal Antibody
Application: WB
Reactivity: Human,Mouse,Rat,
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AZD6482 has been referenced in 1 publications.

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells.

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Average Customer Review

(2 customer reviews)

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  • ;Dr. Zhang of Tianjin Medical University
    AZD6482 purchased from Selleck

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;One customer


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;Dr. Zhang of Tianjin Medical University

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