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Tivozanib (AV-951)

Catalog No. S1207
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Tivozanib (AV-951) Chemical Structure

Bio Information

Tivozanib (AV-951) is an orally bioavailable potent VEGFR-1, 2 and 3, cKit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively. Tivozanib (AV-951) has potential antiangiogenic and antineoplastic activities. Tivozanib (AV-951) inhibits c-Kit and PDGFR at 10-times higher concentrations. Tivozanib (AV-951) is a novel oral quinoline urea derivative. Preclinical data indicate that AV-951 blocks the proliferation and migration of endothelial cells in vitro, and suppresses angiogenesis and growth of human tumor xenografts in vivo. Tivozanib has been shown to be safe and orally bioavailable when given to cancer patients. Tivozanib (AV-951) is under early clinical investigation for the treatment of renal cell carcinoma and non-small cell lung carcinoma, as well as in combination with other chemotherapies in breast, colorectal, and other gastrointestinal cancer patients. [1]

References:

[1] Drugs Fut 2009;34(10): 793

Chemical Information

Molecular Weight (WM): 454.86
Formula:

C22H19ClN4O5
Solubility(R.T.:25°C): DMSO 20mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Quality Control

View current batch:
H-NMR HPLC H-NMR HPLC

Research Area

Protein Tyrosine Kinase >> VEGFR >> VEGFR Inhibitors

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Related Antibodies

Information  
Reactivity: 薛亚红

Tivozanib (AV-951) has been referenced in 0 publications.

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