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ATM (Ataxia telangiectasia mutated) is a serine/threonine protein kinase that plays a central role in orchestrating molecular events involved in cell cycle control, as well as DNA double-strand break signaling and DNA repair. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1009 | BEZ235 (NVP-BEZ235) | BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
 (25)
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 (7)
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| S1092 | KU-55933 | KU-55933 is a potent and specific ATM inhibitor with IC50 and Ki of 13 nM and 2.2 nM, respectively. |
(11)
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(1)
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| S2758 | Wortmannin | Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, respectively. |
(1)
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| S1570 | KU-60019 | KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM. |
(1)
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| S8007 | VE-821 | VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively. |
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| S2245 | CP-466722 | CP-466722 is an potent and reversible ATM inhibitor. |
(2)
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| S2817 | Torin 2 | Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively. |
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