- |
My Account- |
Akt, also known as RAC (related to protein kinase A and C) or protein kinase B (PKB), is a 57 kD serine/threonine kinases family which is the central mediator of the PI3K pathway with numerous downstream molecules that influence important cellular processes, such as cell proliferation, apoptosis, transcription and cell migration. [show the full text]
| Cat.No. | Product Name | Information | Publication | Customer Review |
|---|---|---|---|---|
| S1078 | MK-2206 2HCl | MK-2206 2HCl is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8 nM, 12 nM and 65 nM, respectively. |
 (41)
|
 (6)
|
| S1037 | Perifosine | Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM. |
(17)
|
(9)
|
| S1113 | GSK690693 | GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
(2)
|
(1)
|
| S2808 | GDC-0068 | GDC-0068 is a highly selective pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. |
|
|
| S2743 | PF-04691502 | PF-04691502 is an ATP-competitive PI3K/mTOR inhibitor with IC50 of 32 nM and also inhibits Akt T308/S473 with IC50 of 7.5 nM/3.8 nM. |
|
(1)
|
| S1558 | AT7867 | AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and S6K with IC50 of 32 nM/17 n/47 nM and 85 nM, respectively. |
(3)
|
(4)
|
| S1117 | Triciribine | Triciribine (TCN, API-2) is a DNA synthesis inhibitor and also inhibits Akt and HIV-1 with IC50 of 130 nM and 20 nM, respectively. |
|
|
| S8019 | AZD5363 | AZD5363 is a potent Akt inhibitor for Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively. |
|
|
| S3056 | Miltefosine (Hexadecylphosphocholine) | Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa. |
|
|
| S2732 | Triciribine phosphate (NSC-280594) | Triciribine phosphate (TCN-P, NSC-280594, API-2) is a potent Akt inhibitor with IC50 of 130 nM. |
|
|
| S2670 | A-674563 | A-674563 inhibits Akt1, PKA and CDK2 with Ki of 11 nM, 16 nM and 46 nM, respectively. |
|
(1)
|
