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ABT-263 (Navitoclax)

Catalog No. S1001 5 5 10 Customer Review(s) Product Citations13 Product Citation(s)
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ABT-263 (Navitoclax) Chemical Structure

Bio Information

Overexpression of the prosurvival Bcl-2 family members (Bcl-2,Bcl-xL,and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. Binding affinities were determined with competitive fluorescence polarization assays and a time-resolved fluorescence resonance energy transfer assay (Ki's of <1 nmol/L for Bcl-2, Bcl-xL, and Bcl-w). The oral bioavailability of ABT-263 in preclinical animal models is 20% to 50%, depending on formulation.[1]A wide range of SCLC cellular activity was observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nmol/L against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) resulted in an EC50 at 22 μmol/L. In all cell lines where the EC50 was <1 μmol/L, ABT-263 was more potent than its enantiomer by a factor of >20.[2]

Chemical Information

Molecular Weight (WM): 974.61
Formula:

C47H55ClF3N5O6S3
Solubility(R.T.:25°C): DMSO 195mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Quality Control

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Research Area

Apoptosis >> Bcl-2 >> Bcl-2 Inhibitors

Recommended Screening Libraries

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Related Antibodies

Information  
Reactivity: 薛亚红

ABT-263 (Navitoclax) has been referenced in 13 publications.

BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.
Both TMEM16F-dependent and TMEM16F-independent pathways contribute to phosphatidylserine exposure in platelet apoptosis and platelet activation.
In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution.
Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.
Azacytidine and erlotinib exert synergistic effects against acute myeloid leukemia.
Combination treatments with ABT‐263 and an immunotoxin produce synergistic killing of ABT‐263‐resistant small cell lung cancer cell lines.
Copy number aberrations of BCL2 and CDKN2A/B identified by array-CGH in thymic epithelial tumors.
Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response.
Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer. …
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus.
Pathogen reduction treatment of buffy coat platelet concentrates in additive solution induces proapoptotic signaling.
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

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Average Customer Review

(10 customer reviews)

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  • ;Biochem Biophys Res Commun, 2011, 408(2), 344-9
    ABT-263 (Navitoclax) purchased from Selleck


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  • ;PLoS One , 2011, 6, e21980
    ABT-263 (Navitoclax) purchased from Selleck


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  • ;Clin Cancer Res, 2010, 16, 4217-4225
    ABT-263 (Navitoclax) purchased from Selleck


  • Click to enlarge

  • ;Clin Cancer Res, 2010, 16, 4217-4225
    ABT-263 (Navitoclax) purchased from Selleck


  • Click to enlarge

  • ;Clin Cancer Res, 2010, 16, 4217-4225
    ABT-263 (Navitoclax) purchased from Selleck


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  • ;Cancer Res, 2011, 71, 4518-4526
    ABT-263 (Navitoclax) purchased from Selleck


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  • ;PLoS One, 2011, 6, e21980
    ABT-263 (Navitoclax) purchased from Selleck


  • Click to enlarge

  • ;PLoS One, 2011, 6, e21980
    ABT-263 (Navitoclax) purchased from Selleck


  • Click to enlarge

  • ;Clin Cancer Res, 2010, 16, 4217-4225
    ABT-263 (Navitoclax) purchased from Selleck


  • Click to enlarge

  • Data from [Clin Cancer Res 2010;16, 4217-4225]
    ABT-263 (Navitoclax) purchased from Selleck

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This product has been referenced in

+ See All 13 Product Citations of ABT-263 (Navitoclax)

Check our customer reviews


Click to enlarge

;Biochem Biophys Res Commun, 2011, 408(2), 344-9


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;PLoS One , 2011, 6, e21980

+ See All 10 Customer Reviews of ABT-263 (Navitoclax)

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