Home >> Cytoskeletal Signaling >> HSP (e.g. HSP90) >> HSP (e.g. HSP90) Inhibitors >> 
United States (Change Country)

17-DMAG HCl (Alvespimycin)

Catalog No. S1142 5 5 2 Customer Review(s) Product Citations4 Product Citation(s)
Price Availability Quantity
$ 150 Yes
$ 370 Yes
$ 570 Yes
 
Bulk Inquiry?
processing...
You can order by phone, email or fax

Tel: +1-832-582-8158    Fax: +1-713-796-9816
Email: [email protected]
Free Overnight Delivery on all orders over $ 500.

Order 17-DMAG HCl (Alvespimycin) now
and get it on

17-DMAG HCl (Alvespimycin) Chemical Structure

Bio Information

17-DMAG HCl (Alvespimycin), a watersoluble geldanamycin analog belonging to the class of benzoquinones, is a selective Hsp90 inhibitor. 17-DMAG HCl binds to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. 17-DMAG HCl demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG HCl and 17-AAG respectively), while demonstrating anti-tumor activity and offering excellent oral bioavailability. [1]

 

References:

[1] Cancer Chemother Pharmacol 2005;56: 126–137

Chemical Information

Molecular Weight (WM): 653.21
Formula:

C32H48N4O8•HCl
Solubility(R.T.:25°C): DMSO 131mg/mL 
Water <1mg/mL 
Ethanol <1mg/mL 

Quality Control

View current batch:
H-NMR HPLC

Research Area

Cytoskeletal Signaling >> HSP (e.g. HSP90) >> HSP (e.g. HSP90) Inhibitors

Recommended Screening Libraries

Related Inhibitors

Information  
Elesclomol (STA-4783) is a novel potent oxidative stress inducer that illicits pro-apoptosis events among tumor cells..
  • 5mg
  • $ 170
  • 10mg
  • $ 320
NVP-AUY922 (VER-52296) is a highly potent HSP90 inhibitor for HSP90α and HSP90β with IC50 of 13 nM and 21 nM, respectively.
  • 5mg
  • $ 160
  • 10mg
  • $ 270
17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50of 5 nM.
  • 25mg
  • $ 150
  • 100mg
  • $ 370
Ganetespib is an HSP90 inhibitor with IC50 of 4 nM in OSA 8 cells.
  • 5mg
  • $ 270
  • 10mg
  • $ 370
AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells.
  • 5mg
  • $ 270
  • 10mg
  • $ 370

Related Antibodies

Information  
Reactivity: 薛亚红

17-DMAG HCl (Alvespimycin) has been referenced in 4 publications.

Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells.
Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.
Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis.
Heat-shock protein 90 (Hsp90) is Required for Conidiation and Cell Wall Integrity in Aspergillus fumigatus.

We have 2 customer reviews of 17-DMAG HCl (Alvespimycin).

  • (2)
  • (0)
  • (0)
  • (0)
  • (0)
  • (0)
  • (0)
  • (0)
  • (0)

Average Customer Review

(2 customer reviews)

  • Click to enlarge

  • ;Hepatology, 2013, 57(1), 70-80.
    17-DMAG HCl (Alvespimycin) purchased from Selleck


  • Click to enlarge

  • ;HEPATOLOGY, 2013, 57, 70-80
    17-DMAG HCl (Alvespimycin) purchased from Selleck

Our scientific support team are available to answer any questions or queries.
Fill out an inquiry form for 17-DMAG HCl (Alvespimycin) for help.

Quality Matters

This product has been referenced in

+ See All 4 Product Citations of 17-DMAG HCl (Alvespimycin)

Check our customer reviews


Click to enlarge

;Hepatology, 2013, 57(1), 70-80.


Click to enlarge

;HEPATOLOGY, 2013, 57, 70-80

Your Recent History

Keywords:buy 17-DMAG HCl (Alvespimycin) | 17-DMAG HCl (Alvespimycin) supplier | purchase 17-DMAG HCl (Alvespimycin) | 17-DMAG HCl (Alvespimycin) cost | 17-DMAG HCl (Alvespimycin) manufacturer | order 17-DMAG HCl (Alvespimycin) | 17-DMAG HCl (Alvespimycin) distributor